Home » Weight Loss » Acomplia (Rimonabant)
Diet pill Acomplia (Rimonabant) is a miraculous multifunctional pill that helps you short out obesity as well as smoking. Acomplia diet pills work on the Endocannabinoid system which controls appetite and energy expenditure (as well as the urge to smoke). This wonder pill selectively blocks some receptors in the Endocannabinoid system thus creating a better balance which in turn suppresses appetite and the longing to overeat.
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About Acomplia (Rimonabant):
Product Type: Weight Loss
Brand name: Acomplia
Generic name: Rimonabant
What is Acomplia?
• Acomplia (rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1).
• Acomplia is used in the treatment of obesity and related conditions.
How does Acomplia work?
• Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism including adipose tissue the liver gastrointestinal tract and muscle1.
• Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis.
• CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2 3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance as well as glucose and lipid (or fat) metabolism.
What is Acomplia used for?
• Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood.
• Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease.
• Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug.
Does Acomplia also aid smoking cessation?
• Acomplia has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6 500 smokers motivated to quit smoking.
• Sanofi-aventis submitted a New Drug Application to the FDA which in turn issued a non approvable letter for Acomplia for use in smoking cessation. An approvable letter was however issued for Acomplia for use in weight management.
Acomplia has just been approved in the European Union. Is Acomplia approved in the United States?
• No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year.
• U.S. health authorities have asked Sanofi for more information on Acomplia.
• Acomplia received European Union marketing approval in June 2006.
• The first launch will take place in Britain in July and be followed by launches in Denmark Ireland Germany Finland and Norway in the second half of this year according to Sanofi.
What were the results of Acomplia Clinical trial studies?
• In clinical studies Acomplia has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4 5.
• Approximately half of the observed improvement in HDL-cholesterol triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Acomplia 20mg was beyond that expected from weight loss alone6.
What are the side-effects of Acomplia?
• Side effects in the trial on Acomplia in obesity were vomiting and nausea forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo.
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World Drug News. Government funding crisis in Swaziland disrupts supply of HIV/AIDS supplies. "An acute government funding crisis in Swaziland, Africa's last absolute monarchy, is disrupting supplies of HIV/AIDS drugs and hampering the fight against the virus in the country with the world's highest infection rate, Medecins Sans Frontieres (MSF) said Friday," Reuters reports. "Stocks of testing kits and related chemicals were 'almost dry,' making it next-to-impossible to chart the progress of the 70,000 patients on therapy or more than 130,000 other people carrying the virus, the aid agency said," according to Reuters.
"With 26 percent of its adult population, or more than 200,000 people infected, Swaziland ranks as the most AIDS-affected country," Reuters writes (Cropley, (9/9). In related news, a new report from Swaziland's government "has found that more than half of [30,000 Swazis, mostly women, working] in Swaziland's garment industry are living with HIV, and officials are realizing that the once-hailed promise of manufacturing employment has become a financial and medical nightmare for tens of thousands of Swazi women," PlusNews reports (8/11).
This article was reprinted from kaiserhealthnews.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente.
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